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. 2020 Nov 6;10:19272. doi: 10.1038/s41598-020-76285-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Oroxylin A downregulates the protein level of CHOP during immunoparalysis. CLP mice were injected with oroxylin A (30 mg/kg) at the indicated times, and the protein and mRNA levels of CHOP in peritoneal macrophages (a), PBMCs (b) and splenic lymphocytes (c) were examined at 72 h and 96 h by qPCR and western blotting (n = 6). The data are represented as the mean ± SD, NS > 0.05, Student’s t test. The full-length blots are presented in Supplementary Fig. S11.