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. 2020 Nov 6;11:5653. doi: 10.1038/s41467-020-19425-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — 3D immunolabelling of N-cadherin (magenta) in control (a) or 500 µg/ml Exherin treated (b) En1^Cre;R26^mTmG SCAD. c EPF enrichment index in control or Exherin-treated SCAD. Mean ± SD, p = 0.0001, unpaired two-tailed t-test, n = 8. 3D immunolabelling of decorin (d) or collagen I (e) in a control (upper panel) or Exherin-treated (lower panel, Supplementary Movie 10) SCAD. d′ High magnification of white box in d. f Masson’s trichrome staining of control (upper) or Exherin-treated (lower) SCAD. g Scar areas of control, or DMSO treated or Exherin-treated SCADs. One-way ANOVA Tukey’s test, p = 0.0008, n = 3/6/9. h Fractal dimension analysis of control, or DMSO treated or Exherin-treated SCADs. One-way ANOVA Tukey’s test, p = 0.0001, n = 3/7/7. i Colour-coded tracking of fascia EPFs from live imaging (72–96 h) of 500 µg/ml Exherin-treated En1^Cre;R26^{LSL-H2B-mCherry} SCAD. Colours indicate time, starting from blue to red at the end of the movie (Supplementary Movie 11). Scale bars: a, b, d, i = 100 µm; d′ = 20 µm; e = 50 µm.