Table 4.

Significant radiomics features according to pathologic response for the training set (n = 249). Parameters retained in the final predictive model are italicised.

Parameter	No pCR	pCR	p-value (Mann–Whitney U test)
Mean	114 (90 to 146)	129 (101 to 169)	0.016
Standard deviation	43.9 (32.5 to 63.5)	51.3 (37.2 to 72.4)	0.040
Variance	1596 (803 to 3361)	2989 (1088 to 6079)	0.001
Median	112 (88 to 140)	123 (100 to 161)	0.024
Entropy	3.37 (3.01 to 3.82)	3.59 (3.19 to 3.84)	0.029
Root mean square	127 (99 to 163)	143 (116 to 184)	0.012
Mean absolute deviation	31.9 (24.8 to 47.9)	38.3 (29.3 to 52.8)	0.043
Median absolute deviation	32.0 (24.6 to 47.5)	37.9 (29.4 to 52.4)	0.042
P90	171 (131 to 218)	192 (150 to 236)	0.008
Long run emphasis	2.38 (1.73 to 3.70)	2.56 (1.96 to 4.07)	0.039
Run length variance	0.475 (0.136 to 1.172)	0.779 (0.352 to 1.510)	0.001
Large zone emphasis	1.0 (-126.0 to 188.8)	245.5 (−35.5 to 245.5)	< 0.0001
Zone length variance	-8.0 (-136.9 to 166.1)	249.3 (−44.6 to 249.3)	< 0.0001

Abbreviations: pCR, pathologic complete response.