Fig. 3.

Most frequently mutated miRNA genes and hotspots in Pan-Cancer. (a) miRNA genes with at least 20 somatic mutations in Pan-Cancer. Each colour represents a distinct cancer type. (b) Heatmap showing the percentage of mutations in miRNA genes overmutated (according to functionally weighted analysis) in Pan-Cancer and in specific cancers. Framed squares indicate cancer types in which gene enrichment reached statistical significance (binomial distribution test, adjusted p < 0.01). Specific values of mutation frequencies are shown in Supplementary Table S4. (c) Hotspot positions in miRNA genes with at least 10 somatic mutations in Pan-Cancer (colour legend as in panel a). To simplify the figure, we omitted the prefix hsa-miR in the gene IDs; * note the comment on mutations in hsa-miR-1324 at the end of the section Examples of overmutated miRNA genes.