Fig. 6.

Functional association of overmutated miRNA genes with KEGG pathways. The graph shows the top 20 pathways (y-axis) enriched in protein-coding genes regulated by miRNAs (x-axis) encoded by overmutated miRNA genes. Dot size indicates the number of protein-coding genes; dot colour depicts an adjusted p-value (Fisher's combined probability method) of association. The enrichment analysis was performed with the use of miRPath v3.0 and encompassed the top 100 miRNA genes enriched in the functionally weighted test. The full list of enriched pathways is shown in Supplementary Table S13.