Table 4.
Summary of hotspot positions found in miRNA genes in Pan-Cancer and individual cancer types.
| Cancer type | Significant hotspots (# mutations) | No. of hotspots |
| Pan-Cancer | let-7d chr9:94178817 (23); 1208 chr8:128150186 (7); 1244-2 chr5:118974595 (7); 1249 chr22:45200964 (14); 1277 chrX:118386402 (7); 1302-3 chr2:113583038 (5); 1302-7 chr8:141786250 (5); 1303 chr5:154685809 (6); 1303 chr5:154685819 (8); 1303 chr5:154685820 (12); 1303 chr5:154685821 (12); 1324 chr3:75630794! (69); 1324 chr3:75630855! (77); 1324 chr3:75630860! (5); 15a chr13:50049206 (5); 205 chr1:209432167 (5); 296 chr20:58817670 (6); 320b-2 chr1:224257035 (16); 320c-1 chr18:21683580 (8); 320d-1 chr13:40727811 (15); 320e chr19:46709336 (5); 328 chr16:67202382 (6); 3652 chr12:103930488 (8); 3658 chr1:165907957 (7); 3663 chr10:117167687 (5); 3675 chr1:16858942 (5); 3675 chr1:16859005 (10); 3690-1 chrX:1294009 (14); 4271 chr3:49274155 (8); 4313 chr15:75762211 (5); 4315-1 chr17:45475446 (11); 4329 chrX:112780749 (14); 454 chr17:59137873 (8); 4668 chr9:111932103 (31); 487b chr14:101046508 (5); 489 chr7:93483953 (6); 512-1 chr19:53666774 (6); 512-2 chr19:53669258 (6); 519e chr19:53679964 (11); 519e chr19:53679965 (7); 520b chr19:53701276 (5); 525 chr19:53697575 (13); 525 chr19:53697594 (5); 543 chr14:101032009 (6); 548f-1 chr10:54607963 (6); 550a-3 chr7:29680788 (11); 567 chr3:112112876 (6); 570 chr3:195699434 (5); 602 chr9:137838508 (17); 624 chr14:31014652 (8); 629 chr15:70079384 (10); 633 chr17:62944311 (13); 6742 chr1:228397112 (14); 6811 chr2:237510924 (5); 6821 chr22:49962899 (5); 6859-4 chr16:17058 (9); 6859-4 chr16:17089 (6); 6870 chr20:10649696 (13); 6875 chr7:100868123 (5); 6891 chr6:31355224 (5); 6891 chr6:31355262 (6); 8078 chr18:112283 (10) | 62 |
| ACC | 1324 chr3:75630794! (4); 1324 chr3:75630855! (3) | 2 |
| BRCA | 1324 chr3:75630794! (8); 1324 chr3:75630855! (9); 3690-1 chrX:1294009 (6) | 3 |
| CESC | 1324 chr3:75630794! (5); 1324 chr3:75630855! (5); 629 chr15:70079384 (4); 6891 chr6:31355224 (5) | 4 |
| COAD | 1324 chr3:75630794! (8); 1324 chr3:75630855! (10); 320b-2 chr1:224257035 (5); 320c-1 chr18:21683580 (4); 320d-1 chr13:40727811 (5); 525 chr19:53697575 (5); 602 chr9:137838508 (4); 633 chr17:62944311 (4) | 8 |
| DLBC | 1324 chr3:75630794! (3); 1324 chr3:75630855! (3); 142 chr17:58331260* (3) | 3 |
| ESCA | 1324 chr3:75630794! (8); 1324 chr3:75630855! (9); 624 chr14:31014652 (3) | 3 |
| KICH | 1324 chr3:75630855! (3) | 1 |
| KIRP | 1324 chr3:75630794! (3) | 1 |
| LIHC | 1302-3 chr2:113583038 (5); 1324 chr3:75630794! (7); 1324 chr3:75630855! (7) | 3 |
| OV | 1244-2 chr5:118974595 (3); 376a-2 chr14:101040083* (3); 376c chr14:101039694* (3); 4315-1 chr17:45475446 (6); 519e chr19:53679964 (7); 519e chr19:53679965 (4) | 6 |
| READ | 1324 chr3:75630855! (3) | 1 |
| SARC | 1324 chr3:75630794! (3); 1324 chr3:75630855! (5) | 2 |
| SKCM | 1324 chr3:75630794! (4); 329-1 chr14:101026832* (4); 487b chr14:101046508 (5); 524 chr19:53711049* (4); 525 chr19:53697594 (5) | 5 |
| STAD | 1208 chr8:128150186 (4); 1303 chr5:154685809 (4); 1303 chr5:154685819 (8); 1303 chr5:154685820 (11); 1303 chr5:154685821 (8); 296 chr20:58817670 (5); 454 chr17:59137873 (6); 4668 chr9:111932103 (12); 602 chr9:137838508 (7); 6742 chr1:228397112 (5) | 10 |
| THYM | 1324 chr3:75630794! (4); 1324 chr3:75630855! (7) | 2 |
| UCEC | let-7d chr9:94178817 (16); 1249 chr22:45200964 (8); 1277 chrX:118386402 (7); 1303 chr5:154685821 (4); 320b-2 chr1:224257035 (6); 320c-1 chr18:21683580 (4); 320d-1 chr13:40727811 (8); 3658 chr1:165907957 (5); 4271 chr3:49274155 (6); 4329 chrX:112780749 (12); 4668 chr9:111932103 (16); 602 chr9:137838508 (6); 633 chr17:62944311 (4); 6742 chr1:228397112 (5); 6870 chr20:10649696 (5) | 15 |
⁎
cancer-specific hotspots (not overmutated in Pan-Cancer); underline indicates miRNAs expressed in particular cancers, for more information see Supplementary Table S5; ! note the comment on mutations in hsa-miR-1324 at the end of the section Examples of overmutated miRNA genes. To simplify the table, we omitted the prefix hsa-miR in the gene IDs.