The TSR consistency analysis. (a) Example of HE image blocks, pathologist annotations, and the CNN model prediction map. (b) Concordance between TSR estimated by CNN model and the pathologist. (c) Bland–Altman plot for TSR estimation. The solid horizontal line is the mean, the dashed line is zero, and the shaded regions are 95% CIs. TSR, tumour-stroma ratio; HE, haematoxylin–eosin; CNN, convolutional neural network; CI, confidence interval.