Table 2.
Uni- and multivariate analyses including age, sex, stage, tumour site, and TSR for OS in the two cohort.
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Discovery cohort | Validation cohort | Discovery cohort | Validation cohort | |||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Age | 1.02(1.01-1.04) | <0.001 | 1.01 (0.99-1.03) | 0.184 | 1.02 (1.01-1.04) | <0.001 | 1.02 (1.00-1.03) | 0.103 |
| Sex | ||||||||
| Male | 1 | |||||||
| Female | 0.93 (0.68-1.28) | 0.664 | 1.44 (0.90-2.28) | 0.125 | ||||
| Stage | ||||||||
| I | 1 | 1 | ||||||
| II | 2.70 (1.15-6.37) | 0.023 | 1 | 2.40 (1.02-5.68) | 0.046 | 1 | ||
| III | 7.20 (3.16-16.4) | <0.001 | 3.10 (1.80-5.35) | <0.001 | 6.47 (2.84-14.8) | <0.001 | 2.98 (1.73-5.15) | <0.001 |
| IV | 24.3 (8.40-70.0) | <0.001 | 24.7 (8.47-71.7) | <0.001 | ||||
| Tumour site | ||||||||
| Colon | 1 | 1 | ||||||
| Rectum | 0.99 (0.72-1.39) | 0.998 | 1.12 (0.71-1.78) | 0.625 | ||||
| TSR | ||||||||
| Stroma-low | 1 | 1 | 1 | 1 | ||||
| Stroma-high | 1.79 (1.30-2.47) | <0.001 | 2.17 (1.32-3.57) | 0.002 | 1.72 (1.24-2.37) | 0.001 | 2.08 (1.26-3.42) | 0.004 |
Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; TSR, tumour-stroma ratio.