Table 2.
Summary of Correlations Between Maternal Iron Biomarkers and Neonatal Iron and Haematological Indices.
| Mother | Neonate | Number of Studies and References | Pooled weighted mean correlation coefficient (95% CI)(Schmidt-Hunter) |
|---|---|---|---|
| Ferritin (n = 29) | Ferritin | 27[23,27,30,32,33,35,38,41,[43], [44], [45],48,51,57,58,59,62,64,66,69,72,76,77,[80], [81], [82], [83]] | 0.14 (0.07, 0.20) – Negligible P<0.0001 |
| Hepcidin | 1[76] | Not calculated | |
| Plasma/serum iron | 6[27,30,58,59,64,76] | 0.21 (−0.02, 0.45) – Negligible P = 0.08 |
|
| Tf Sat | 5[27,30,59,64,76] | 0.10 (−0.19, 0.39) – Negligible P = 0.50 |
|
| TIBC | 6[27,30,58,59,64,76] | −0.09 (−0.33, 0.14) – Negligible P = 0.43 |
|
| ZPP | 1[64] | Not calculated | |
| Hb | 8[27,32,38,57,64,66,74,76] | 0.05 (−0.05, 0.15) – Negligible P = 0.32 |
|
| MCHb | 2[27,38] | Not calculated | |
| MCV | 3[27,38,64] | 0.15 (−0.06, 0.35) – Negligible P = 0.16 |
|
| Hepcidin (n = 4) | Ferritin | 1[76] | Not calculated |
| Hepcidin | 4[76,79,77,81] | 0.42 (0.18, 0.66) – Low positive P = 0.001 |
|
| Plasma/serum iron | 1[76] | Not calculated | |
| Tf Sat | 1[76] | Not calculated | |
| TIBC | 1[76] | Not calculated | |
| Hb | 1[76] | Not calculated | |
| Serum Iron (n = 23) | Ferritin | 5[27,58,59,64,76] | 0.33 (0.13, 0.52) – Low positive P = 0.001 |
| Hepcidin | 1[76] | Not calculated | |
| Plasma/serum iron | 23[22,27,29,31,33,[35], [36], [37],46,50,[53], [54], [55],[57], [58], [59],64,67,68,73,74,76,80] | 0.30 (0.19, 0.40) – Low positive P<0.0001 |
|
| Tf Sat | 4[27,59,64,76] | 0.35 (0.12, 0.58) – Low positive P = 0.003 |
|
| TIBC | 5[27,58,59,64,76] | −0.15 (−0.39, 0.09) – Negligible P = 0.22 |
|
| ZPP | 1[64] | Not calculated | |
| Hb | 4[27,54,64,76] | 0.42 (0.09, 0.75) – Low positive P = 0.01 |
|
| MCHb | 1[27] | Not calculated | |
| MCV | 2[27,64] | Not calculated | |
| sTfR (n = 2) | sTfR | 2[77,81] | Not calculated |
| Tf (n = 3) | Tf | 3[42,40,71] | 0.09 (−0.08, 0.26) – Negligible P = 0.28 |
| Tf Sat (n = 9) | Ferritin | 4[30,59,64,76] | 0.07 (−0.23, 0.38) – Negligible P = 0.64 |
| Hepcidin | 1[76] | Not calculated | |
| Plasma/serum iron | 4[30,59,64,76] | 0.18 (−0.05, 0.41) – Negligible P = 0.12 |
|
| Tf Sat | 9[29,30,33,35,36,55,59,64,76] | 0.20 (0.08, 0.31) – Negligible P = 0.001 |
|
| TIBC | 4[30,59,64,76] | 0.06 (−0.22, 0.34) – Negligible P = 0.69 |
|
| ZPP | 1[64] | Not calculated | |
| Hb | 2[64,76] | Not calculated | |
| MCV | 1[64] | Not calculated | |
| TIBC (n = 8) | Ferritin | 5[30,58,59,64,76] | 0.04 (−0.21, 0.29) – Negligible P = 0.75 |
| Serum Iron | 5[30,58,59,64,76] | 0.02 (−0.20, 0.24) – Negligible P = 0.85 |
|
| Tf Sat | 4[30,59,64,76] | −0.09 (−0.34, 0.16) – Negligible P = 0.47 |
|
| TIBC | 8[29,30,33,55,58,59,64,76] | 0.16 (0.01, 0.31) – Negligible P = 0.03 |
|
| ZPP | 2[64,76] | Not calculated | |
| Hb | 1[76] | Not calculated | |
| MCV | 1[64] | Not calculated | |
| ZPP (n = 2) |
Ferritin | 1[64] | Not calculated |
| Plasma/serum iron | 1[64] | Not calculated | |
| Tf | 1[61] | Not calculated | |
| Tf Sat | 1[64] | Not calculated | |
| TIBC | 1[64] | Not calculated | |
| ZPP | 1[64] | Not calculated | |
| Hb | 2[61,64] | Not calculated | |
| MCV | 1[64] | Not calculated |
Hb=haemoglobin; MCHb=mean corpuscular haemoglobin; MCV=mean cell volume; NOS=Newcastle-Ottawa scale;.
sTfR=soluble/serum transferrin receptor; TIBC=total iron binding capacity; Tf=transferrin; Tf Sat=transferrin saturation; ZPP= zinc protoporphyrin.