Table 4.
Univariate and multivariate Cox regression analysis of of clinicopathological data correlated with OS in radiation-treated sarcoma.
| Factors | n | Univariate |
Multivariate (n=60) |
||
|---|---|---|---|---|---|
| HR (95% CI)a | Pa | HR (95% CI)b | Pb | ||
| Sex (Male/Female) | 73 | 1.218 (0.568-2.611) | 0.613 | •• | •• |
| Age,years (≤62/>62) | 73 | 1.547 (0.722-3.316) | 0.262 | 1.819 (0.667-4.963) | 0.242 |
| Local disease recurrence (No/Yes) | 60 | 2.964 (1.192-7.368) | 0.019 | 3.139 (0.996-9.891) | 0.051 |
| Tumor depth (Superficial/Deep) | 63 | 2.947 (0.395-21.961) | 0.292 | •• | •• |
| Tumor necrosis percent (≤15/>15) | 38 | 1.405 (0.503-3.928) | 0.517 | •• | •• |
| Race (Other/White) | 70 | 0.921 (0.216-3.927) | 0.912 | •• | •• |
| New tumor event after initial Treatment | |||||
| (No/YES) | 46 | 111.064 (0.333-37090.821) | 0.112 | •• | •• |
| Metastatic diagnosis (No/YES) | 63 | 3.090 (1.330-7.180) | 0.009 | 1.397 (0.437-4.465) | 0.573 |
| ASPM (low/high) | 73 | 3.004 (1.323-6.820) | 0.009 | 1.030 (0.180-5.893) | 0.973 |
| GTSE1 (low/high) | 73 | 2.213 (1.006-4.868) | 0.048 | 0.619 (0.097-3.972) | 0.613 |
| KIF18B (low/high) | 73 | 4.179 (1.761-9.920) | 0.001 | 7.773 (1.113-54.315) | 0.039 |
| UHRF1 (low/high) | 73 | 2.228 (1.014-4.897) | 0.046 | 0.863 (0.159-4.692) | 0.864 |
| DES (low/high) | 73 | 3.458 (1.458-8.198) | 0.005 | 2.721 (0.832-8.904) | 0.098 |
| CLIC5 (low/high) | 73 | 0.372 (0.169-0.822) | 0.014 | 0.471 (0.159-1.401) | 0.176 |
| CCDC69 (low/high) | 73 | 0.372 (0.167-0.831) | 0.016 | 0.285 (0.087-0.932) | 0.038 |
a
P value, HR and 95% CI were assessed using univariate Cox regression analysis.
b
P value, HR and 95% CI were assessed using multivariate Cox regression analysis.
HR, hazard ratio; 95% CI, 95% confidence interval. OS, overall survival. ••, no data to display.