Figure 5.

Correlation of Differential Methylation and Gene Expression in BCR-ABL⁺ Cdk6^−/− Cells Compared to BCR-ABL⁺ Cdk6^wt Cells

(A) Heatmaps showing fold changes in DNA methylation (green panels) and gene expression (violet panels) determined by RNA-sequencing. Fold changes range from red (positive) to blue (negative). The 3 cell lines are presented separately.

(B) Association of hypermethylated/downregulated genes (red rectangles) and hypomethylated/upregulated genes (blue rectangles) with certain cancer-related molecular pathways. See also Figure S8.