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. 2020 Oct 7;23(10):101603. doi: 10.1016/j.isci.2020.101603

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

A Model for the Role of Tcb Proteins in Non-vesicular Ceramide Transport and LD Formation

Tcb proteins are required for non-vesicular transport of ceramide at ER-medial-Golgi contact sites. The SMP domains in Tcb proteins may transfer ceramide, and the C2 domains may tether the ER to the medial-Golgi via the interaction with acidic phospholipids. Ceramide transport defects result in ceramide accumulation, which may increase acylceramide formation, thereby facilitating LD formation to alleviate cells from ceramide toxicity.