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. 2020 Nov 2;12:11031–11040. doi: 10.2147/CMAR.S272983

Figure 4.

Figure 4

TNFAIP3 is a target of miR-138-5p. (A) The binding sites of miR-138-5p in TNFAIP3 3ʹUTR were shown via the starBase v2.0 database. (B and C) Luciferase intensity was detected in Huh7-1.3 and HepG2.2.15 cells introduced with TNFAIP3 3ʹUTR-WT or TNFAIP3 3ʹUTR-MUT and miR-NC or miR-138-5p. (D and E) The mRNA and protein levels of TNFAIP3 were measured in HBV-associated HCC tissues and adjacent non-cancer tissues. (F) TNFAIP3 protein expression was detected in HCC cells with or without HBV infection. (G) The correlation between miR-138-5p and TNFAIP3 was tested using Spearman correlation coefficient. ***P < 0.001, ****P < 0.0001.

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