Fig. 5.

Preoperative CT findings and postoperative histologic evaluations of pancreatic stumps: (a) preoperative CT scans of patients with differing CR-POPF risks are shown, ranging from high (first row) to moderate (second row) and low (third row) risk based on CT-FRS model. In the first column, ROIs are delineated in pancreatic remnants, whereas the segmented pancreatic remnants of second column exclude ductal volumes. The final three columns reveal histologic features of remnant pancreas stained by H&E, Masson's trichrome, and Sirius Red, respectively. From high to low risk, both pancreatic fibrosis and glandular atrophy had progressed; and (b-d) CT-FRS probabilities correspond with stages of fibrosis (F0, F1, F2-F3), degrees of glandular atrophy (no [A0], mild [A1] and severe [A2]), and extents of lipomatosis (no [L0], mild [L1-L2], severe [L3]), decreasing as fibrosis and glandular atrophy advance, and increasing as lipomatosis advances. All CT-FRS probabilities in CR-POPF risk groups (purple columns) were significantly higher than those in non CR-POPF groups (gray columns) at each histologic stage or grade. Scale bars represent 250 μm.