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. 2020 Nov 6;3(11):e2019176. doi: 10.1001/jamanetworkopen.2020.19176

Table 2. Laboratory Studies on Initial Presentation.

Laboratory study Median (IQR)
White blood cell count, /μL 15 300 (12 300-17 900)
Differential, median (IQR), %
Granulocytes 90.3 (88.0-92.4)
Lymphocytes 5.7 (4.2-7.9)
Monocytes 2.4 (2-3.2)
Basophils 0.2 (0.1-0.3)
Eosinophils 0.3 (0.1-0.9)
ESR, mm/h 75 (42-100)
CRP, mg/dL 25.8 (18.7-30.2)
Elevated, No./total No. (%)
ESRa 25/26 (96)
CRPb 27/27 (100)
ESR or CRP 28/28 (100)
ESR >100 mm/h 7/26 (27)
Procalcitonin, ng/mL 0.3 (0.1-0.7)
Creatinine, mg/dL 0.85 (0.73-0.94)
Total bilirubin, mg/dL 1.0 (0.6-1.4)
AST, U/L 31 (25-37)
ALT, U/L 24 (18-39)
Elevated, No./total No. (%)
ASTc 6/30 (20)
ALTd 5/30 (17)
AST or ALT 7/30 (23)
Alkaline phosphatase, U/L 85 (72-114)
HIV 1, 2 antigen or antibody
Negative, No./total No. (%) 19/19 (100)
BAL performed, No./total No. (%) 24/31 (77)
Cytologic differential, %
Macrophages 53 (33-79)
Neutrophils 28 (12-48)
Lymphocytes 6 (2-12)
Eosinophils 0 (0-2)
Presence of LLMs, No./total No. (%)e 21/23 (91)
LLMs, median (IQR), % 52 (33-76)
Urine drug screen, No./total No. (%)
Marijuana 11/11 (100)
Cocaine 0/11
Heroin 0/1
Methamphetamine 1/11 (9)
Narcotics 2/11 (18)
Benzodiazepine 0/11
Methadone 0/11
Buprenorphine 0/11

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BAL, bronchoalveolar lavage; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IQR, interquartile range; LLM, lipid-laden microphage.

SI conversion factors: To convert AST, ALT, and alkaline phosphatase to microkatals per liter, multiply by 0.0167; creatinine to micromoles per liter, multiply by 76.25; CRP to milligrams per liter, multiply by 10; total bilirubin to micromoles per liter, multiply by 17.104; and white blood cell count to ×109/μL, multiply by 0.001.

a

Greater than upper reference limit (20 mm/h).

b

Greater than upper reference limit (0.8 mg/dL).

c

Greater than upper reference limit (40 U/L).

d

Greater than upper reference limit (60 U/L).

e

One patient who underwent BAL did not have LLM testing performed.