Table 2.
Citrullinated peptides identified in extracellular vesicles present in the synovial fluid of rheumatoid arthritis (RA) patients
| Accession | Protein name | Citrullinated peptide sequence a | Mass‐to‐charge ratio (m/z) | Parts per million | Retention time |
−10LogP (PEAKS) |
Score (MQ) |
Sample detected in/ACPA status |
|---|---|---|---|---|---|---|---|---|
| P16070|CD44_HUMAN | CD44 antigen | ESSETPDQFMTADETcitRNLQNVDMK | 929.7452 | 0.8 | 62.7 | 82.14 | 138.08 |
RA‐HIGH_2/ ACPA‐negative |
|
P63261|ACTG_HUMAN: P60709|ACTB_HUMAN |
Actin cytoplasmic 2 | IWHHTFYNELcitRVAPEEHPVLLTEAPLNPK | 691.1657 | 2.0 | 66.5 | 71.15 | 84.52 |
RA‐HIGH_2/ ACPA‐negative |
| P02671|FIBA_HUMAN | Fibrinogen alpha chain | GDFSSANNcitRDNTYNR | 577.9180 | 0.7 | 11.7 | 65.31 | 100.54 |
RA‐HIGH_5/ ACPA‐positive |
| P21730|C5AR1_HUMAN | C5a anaphylatoxin chemotactic receptor 1 | SFTcitRSTVDTMAQK | 491.5763 | 2.6 | 27.3 | 54.95 | 109.42 |
RA‐HIGH_2/ ACPA‐negative |
| Q92954|PRG4_HUMAN | Proteoglycan 4 | AITTcitRSGQTLSK | 632.3525 | 2.1 | 8.7 | 48.71 | NA |
RA‐HIGH_5/ ACPA‐positive |
| P31146|COR1A_HUMAN | Coronin‐1A | citRAAPEASGTPSSDAVSR | 830.4032 | −0.2 | 13.6 | 48.01 | NA |
RA‐HIGH_2/ ACPA‐negative |
| P84095|RHOG_HUMAN | Rho‐related GTP‐binding protein RhoG | TVNLNLWDTAGQEEYDcitRLR | 765.7108 | 0.3 | 30.1 | 45.34 | 113.05 |
RA‐HIGH_2/ ACPA‐negative |
|
Q71DI3|H32_HUMAN: P68431|H31_HUMAN: P84243|H33_HUMAN |
Histone H3.2 | YRPGTVALcitREIR | 477.9438 | 3.2 | 30.1 | 42.79 | NA |
RA‐HIGH_5/ ACPA‐positive |
| P02671|FIBA_HUMAN | Fibrinogen alpha chain | MELEcitRPGGNEITR | 501.5828 | 1.6 | 25.7 | 37.03 | NA |
RA‐HIGH_4/ ACPA‐positive |
a
The position of citrullinated arginine residues are indicated in bold.