Table 4.

Highest ranked synovial fluid extracellular vesicle (EV) proteins across all rheumatoid arthritis (RA) patients

Rank	UniProt gene	UniProt protein	RA ‐ all patients (avg. iBAQ)	RA high‐level inflammation (avg. iBAQ)	RA low‐level inflammation (avg. iBAQ)	OA (avg. iBAQ)	Potential involvement in RA/EV biology	Reference
1	ANXA2	Annexin A2	770 724	955 269	512 361	417 606	Potential autoantigen	Salle et al. 2008 52
2	GLIPR2	Golgi‐associated plant pathogenesis‐related protein 1	713 566	954 927	375 660	53 732	Epithelial cell migration	Huang et al. 2013 53
3	FGB	Fibrinogen beta chain	773 331	1 031 950	411 263	152 131	Defined autoantigen	Muller & Radic 2015 19
4	ANXA1	Annexin A1	545 978	816 539	167 194	137 854	Cartilage regeneration	Headland et al. 2015 7
5	MSN	Moesin	329 042	398 267	232 126	77 226	EV migration	Dalli et al. 2013 29
5	ANXA4	Annexin A4	309 971	388 451	200 099	114 765	EV membrane integrity	Boye et al. 2017 54
7	ACTB	Actin, cytoplasmic 1	409 856	396 346	428 769	132 114	Defined autoantigen	Darrah et al. 2012 15
8	IGKC	Ig kappa chain C region	769 398	1 124 444	272 333	41 868	Adaptive immune response	Klareskog et al. 2014 55
9	ARF1	ADP‐ribosylation factor 1	300 485	390 117	175 000	95 091	EV biogenesis	Record et al. 2018 56
10	ANXA6	Annexin A6	276 676	355 757	165 962	90 493	EV membrane integrity	Boye et al. 2017 54

iBAQ, intensity‐based absolute quantification.