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. 2020 Nov 7;20:180. doi: 10.1186/s12894-020-00751-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — NDA HIC tissues exhibited increased expression of immune response proteins, with decreased protein expression for Rap1 signaling and general metabolism. Association map for proteins differentially expressed in NDA Hunner’s IC biopsies compared to NDA non-Hunner’s IC biopsies. Nodes in the green box were increased in NDA HIC samples, while nodes in the red box were decreased. White nodes represent immune response proteins, while blue and red nodes represent protein metabolism and Rap1 signaling proteins, respectively. Lines between nodes indicate reported associations as detailed in “Methods” section