Table 3.

Diseased Hunner’s IC biopsies compared to diseased non-Hunner’s IC biopsies

Accession ID	Gene Name	Description	Fold change (FC ≥ 4)	p value (p ≤ 0.05)
		Immune and inflammatory response (up-regulated) 10 of 34 significant proteins	Diseased HIC/diseased NHIC
P11678	EPX	Eosinophil peroxidase	74.7	0.0184
P08575	PTPRC	Tyrosine phosphatase C	45.9	0.0163
P12724	RNASE3	Eosinophil cationic protein	19.6	0.0072
P13727	PRG2	Bone marrow proteoglycan precursor	13.6	0.0046
P01889	HLA-B	HLA class I histocompatibility antigen, B-41	10.5	0.0011
P51665	PSMD7	26S proteasome non-ATPase regulatory subunit	9.16	0.0481
P04440	HLA-DPB1	HLA class II histocompatibility antigen, DP beta 1 chain	6.77	0.0079
Q8NBS9	TXNDC5	Thioredoxin domain-containing protein 5	5.55	0.0065
P22897	MRC1	Mannose-receptor C-type 1	5.91	0.0303
Q9Y2Y8	PRG3	Proteoglycan 3	4.46	0.0038
		ER protein processing & ER stress (up-regulated) 9 of 34 significant proteins
Q8TCJ2	STT3B	Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B	22.2	0.026
Q9UNL2	SSR3	Translocon-associated protein subunit gamma	13.6	0.0135
Q2P2E9	RRBP1	Ribisome-binding protein 1	11.2	0.0119
Q9UBS4	DNAJB11	DnaJ Homolong subfamily B member 11	11.1	0.0008
P46977	STT3A	Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A	8.79	0.0248
P49257	LMAN1	Protein ERGIC-53	5.97	0.0244
Q8NBS9	TXDNC5	Thioredoxin domain-containing protein 5	5.55	0.0065
Q12907	LMAN2	Vesicular integral-membrane protein VIP36	5.27	0.0028
P51571	SSR4	Translocon-associated protein subunit delta	4.04	0.0091
		Cellular adhesion (down-regulated) 5 of 42 significant proteins	Diseased NHIC/Diseased HIC
Q14031	COL4A6	Collagen alpha-6(IV)	12.6	0.0144
P35221	CTNNA1	Catenin alpha-1	9.54	0.0005
O60716	CTNND1	Catenin delta-1	5.69	0.0288
P02461	COL3A1	Collagen alpha-1(III)	4.62	0.0039
Q99715	COL12A1	Collagen alpha-1(XII)	4.46	8.13e-5