Fig. 7.

W20/XD4-SPIONs promoted microglial engulfment of Aβ in AD mice. a Representative images of Iba-1 positive microglia (green) and engulfed Aβ puncta (red) in WT and AD mice treated with various SPIONs. b Quantification of Aβ puncta engulfed in Iba-1 positive microglia, normalized to PBS-treated AD controls. Scale bars 500 nm. Data represent means ± SEM and were analyzed by one-way ANOVA with Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001