Drug 1
Generic/Working Name	Pemetrexed sodium for injection
Dose	500 mg/m2
Route	IV
Schedule of Administration
The control group received four cycles of docetaxel or pemetrexed single‐agent chemotherapy and were monitored by regular follow‐up. The withdrawal of drugs because of drug‐related toxicity was for <14 days and not more than two times. The patients in the pemetrexed group were treated with 4 mg dexamethasone 1 day before administration, on the same day, and 1 day after administration, twice a day. At least five daily doses of folic acid (350–1000 μg) were administered 7 days prior to the first treatment and continued until 21 days after the final pemetrexed dose. One thousand micrograms of vitamin B12 should also be injected intramuscularly within 7 days prior to the first pemetrexed administration and once every three cycles thereafter. The granulocyte colony‐stimulating factor was permitted for prophylactic use in patients with granulocytopenia events or those that occurred during the previous cycle of treatment.
Drug 2
Generic/Working Name	Docetaxel injection
Dose	75 mg/m2
Route	IV
Schedule of Administration
The control group received four cycles of docetaxel or pemetrexed single‐agent chemotherapy and were monitored by regular follow‐up. The withdrawal of drugs because of drug‐related toxicity was for <14 days and not more than two times. The patients in the docetaxel treatment group received 8 mg dexamethasone 1 day before administration, on the same day, and 1 day after administration, twice a day. The granulocyte colony‐stimulating factor was permitted for prophylactic use in patients with granulocytopenia events or those that occurred during the previous cycle of treatment.