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. 2020 Sep 14;25(11):943–953. doi: 10.1634/theoncologist.2020-0449

Figure 2.

Figure 2

Comutation plots of the top 20 genes for each breast carcinoma cohort stratified based on biomarker status of HR and HER2. Here, we see that although there was some overlap in the top 20 genes in each cohort (HR+/HER2−, HER2+, and TNBC) there were some differences. For the HR+/HER2− cohort, the top 5 genes in descending order were PIK3CA, TP53, RAD21, NBN, and CCND1; for the HER2+ cohort, they were TP53, CDK12, PIK3CA, MYC, and RAD21; and for the TNBC cohort, they were TP53, RAD21, MYC, PIK3CA, and NBN. Abbreviations: −, negative; +, positive; HR, hormone receptor; TNBC, triple‐negative breast cancer.