Table 3.
Top five candidate lncRNAs highly prioritized to be associated with ASD.
| Gene ID | Gene symbol | Annotation | Co-expressed protein-coding genes in the BrainSpan dataset (PCC>0.95)* |
Traits reported in GWAS Catalog** |
|---|---|---|---|---|
| ENSG00000229807 | XIST | X inactive specific transcript | \ | \ |
| ENSG00000240801 | AC132217.1 | 3' overlapping ncRNA IGF2 | IGF2 | Birth weight |
| ENSG00000228971 | LINC02607 | Long intergenic non-protein coding RNA 2607 | \ | Intelligence, cognitive performance |
| ENSG00000258283 | AC011603.4 | Antisense to DDN | DDN | Intelligence, cognitive ability, Bipolar disorder |
| ENSG00000221857 | AC020907.2 | Novel transcript | GNPTG, NDRG2, TNFSF12, TNFSF12-TNFSF13 | \ |
*The protein-coding genes co-expressed with the candidate lncRNAs in the BrainSpan dataset are indicated. Pearson Correlation Coefficient (PCC) > 0.95 was used to select the co-expressed gene pairs.
**Traits reported to be associated with the genomic loci from which the candidate lncRNAs are transcribed. Information was retrieved from GWAS Catalog (https://www.ebi.ac.uk/gwas/).