Table 3.
Cox proportional hazard regression unadjusted and adjusted analysis of time to sputum culture conversion*
| Characteristics | Univariate HR (95% CI) | p- value | Multivariate HR (95% CI) | p- value | |
|---|---|---|---|---|---|
| Age | 1.01 (0.99–1.02) | 0.483 | 0.994 (0.98–1.01) | 0.593 | |
| Emphysema | 2.21 (1.36–3.60) | 0.001 | 2.43 (1.18–4.97) | 0.015 | |
| Smoking history | 1.81 (1.09–2.99) | 0.021 | 0.87 (0.44–1.72) | 0.692 | |
| Current smoker | 1.26 (0.77–2.04) | 0.361 | |||
| Consolidation | 1.77 (1.06–2.96) | 0.031 | 1.07 (0.61–1.87) | 0.818 | |
| Cavities | 2.72 (1.65–4.49) | < 0.0001 | 2.15 (1.18–3.89) | 0.012 | |
| Alcohol consumption | 1.19 (0.73–1.94) | 0.478 | |||
| Diabetes† | 1.67 (0.99–2.82) | 0.055 | |||
| CKD‡ | 0.83 (0.48–1.41) | 0.482 | |||
| Hypoalbuminemia§ | 1.74 (1.08–2.80) | 0.024 | 0.99 (0.53–1.86) | 0.979 | |
| Autoimmunity | 0.44 (0.18–1.11) | 0.081 | |||
| Steroid use | 0.83 (0.38–1.82) | 0.641 | |||
| Malignancy | 1.02 (0.51–2.06) | 0.956 | |||
| TTD within 2 weeks at baseline | 2.56 (1.52–4.31) | < 0.0001 | 2.95 (1.64–5.31) | < 0.0001 | |
| Treated with HREZ | 1.40 (0.85–2.31) | 0.181 | |||
*HR calculated with each per unit increase. Each variable measured at the time of diagnosis. Adjusted by previously described clinically important variables and candidate variables (age, emphysema, smoking history, consolidation, cavities, hypoalbuminemia and TTD within 2 weeks) for which the p- value was < 0.05 on univariate analysis
†Diabetes: prescription of oral hypoglycaemic agents and/or insulin; fasting blood glucose ≥126 mg/dL or haemoglobin A1c ≥6.5%. ‡ CKD: glomerular filtration rate < 60 mL/min/1.73 m2 for > 3 months. § Hypoalbuminemia: serum albumin ≤3.5 g/dL