TABLE 3.
Partial Spearman correlation (ρ) coefficients between diffusion measure and select neuropsychological instruments, after adjusting for age. Unadjusted P‐values are reported as all comparisons were predefined
| Left hemisphere | Right hemisphere | |||||
|---|---|---|---|---|---|---|
| Diffusion measure | Tract | ρ (95% CI) | P value | ρ (95% CI) | P value | |
| Total memory score | AxD | CCG | −0.33 (−0.59, 0.00) | 0.051 | −0.36 (−0.60, −0.05) | 0.024 |
| FA | CCG | 0.09 (−0.21, 0.38) | 0.554 | 0.20 (−0.10, 0.46) | 0.195 | |
| MD | CCG | −0.36 (−0.62, −0.03) | 0.032 | −0.38 (−0.62, −0.07) | 0.017 | |
| RD | CCG | −0.29 (−0.55, 0.03) | 0.072 | −0.30 (−0.55, 0.00) | 0.051 | |
| AxD | FMajor | −0.14 (−0.42, 0.16) | 0.357 | |||
| FA | FMajor | 0.26 (−0.02, 0.50) | 0.067 | |||
| MD | FMajor | −0.31 (−0.56, 0.00) | 0.048 | |||
| RD | FMajor | −0.31 (−0.55, −0.02) | 0.039 | |||
| AxD | FMinor | −0.32 (−0.55, −0.04) | 0.024 | |||
| FA | FMinor | 0.41 (0.10, 0.65) | 0.012 | |||
| MD | FMinor | −0.41 (−0.65, −0.09) | 0.014 | |||
| RD | FMinor | −0.44 (−0.69, −0.12) | 0.010 | |||
| Cued Recall | AxD | CCG | −0.30 (−0.57, 0.04) | 0.078 | −0.27 (−0.54, 0.05) | 0.010 |
| FA | CCG | 0.16 (−0.17, 0.46) | 0.340 | 0.25 (−0.05, 0.50) | 0.097 | |
| MD | CCG | −0.34 (−0.61, 0.00) | 0.051 | −0.30 (−0.57, 0.03) | 0.077 | |
| RD | CCG | −0.27 (−0.55, 0.06) | 0.110 | −0.29 (−0.56, 0.04) | 0.084 | |
| FA | FMajor | 0.32 (0.04, 0.56) | 0.029 | |||
| MD | FMajor | −0.36 (−0.60, −0.06) | 0.021 | |||
| RD | FMajor | −0.34 (−0.59, −0.04) | 0.026 | |||
| FA | FMinor | 0.47 (0.19, 0.68) | 0.002 | |||
| MD | FMinor | −0.25 (−0.54, 0.09) | 0.146 | |||
| RD | FMinor | −0.34 (−0.61, 0.00) | 0.048 | |||
| Rivermead | RD | FMajor | −0.24 (−0.49, 0.03) | 0.083 | ||
| FA | FMinor | 0.44 (0.15, 0.66) | 0.004 | |||
| RD | FMinor | −0.24 (−0.48, 0.04) | 0.088 | |||
| TSI | FA | FMinor | 0.46 (0.19, 0.68) | 0.002 | ||
Abbreviations: AxD, axial diffusivity; ATR, anterior thalamic radiation; CAB, cingulum‐angular bundle; CCG, cingulum‐cingulate gyrus bundle; CST, corticospinal tract; FA, fractional anisotropy; FDR, false discovery rate; FMajor, forceps major; FMinor, forceps minor; ILF, inferior longitudinal fasciculus; MCI‐DS, mild cognitive impairment‐Down syndrome; MD, mean diffusivity; RD, radial diffusivity; SLFp, superior longitudinal fasciculus‐parietal bundle; SLFt, L/R superior longitudinal fasciculus‐temporal bundle; UNC, uncinate fasciculus.