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. 2020 Nov 7;142:111147. doi: 10.1016/j.exger.2020.111147

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Fig. 2 — Age-related mitochondrial dysfunction increases the inflammatory response to SARS-CoV-2. The activation of the inflammasome caused by mitochondrial dysfunction during aging and age-related diseases contributes to the chronic inflammation and the release of inflammatory cytokines in the elderly. This system produces a vicious cycle that feed the activity of the inflammasome. When SARS-CoV-2 invades the organism, macrophages showing a high activity of inflammasome can enhance the release of inflammatory cytokines generating the characteristic cytokine storm associated with COVID-19.