Figure 4.

Cytokine increase. Heat maps (A) separated by species (first row), animal (second row), and timepoint (third row) showing changes in the levels of 10 cytokines in plasma at week 1 (purple, first two heat maps) and necropsy (orange, third and fourth heat maps) with respect to the baseline in African green monkeys (AGMs) and rhesus macaques (RMs). AGMs at 1 week post-infection (heat map 1) show increased levels of interferon (IFN)-γ, which is not observed in RMs at the same timepoint (heat map 2). At necropsy, three of the four AGMs exhibit elevated levels of multiple plasma cytokines (heat map 3) in contrast to RMs (heat map 4). Data are normalized (log₂). B: Levels of IFN-γ in plasma at baseline, week 1, and at necropsy. C: Association between IFN-γ levels at week 1 and viral load in bronchial brushes (Pearson test). TNF-α, tumor necrosis factor-α.