. 2020 Nov 3;12:139–167. doi: 10.2147/EB.S277760

Table 6.

Summary of Cases— Other

Author Year Ref	Age M/F	Cancer Type	ICI Name	Cycles and Duration Before Symptoms	Neuro-Ophthalmic Diagnosis	For Myositis: EOMs Normal or Abnormal Size	Ophthalmic Presentation	Treatment	ICI Continued/Held/Terminated	Neuro-Ophthalmic Outcome	Follow-up Period (Months)
Maller 2018¹³⁴	74M	Epithelioid mesothelioma	Ipilimumab and nivolumab	2 ipilimumab and 5 nivolumab infusions: then 10 weeks	Opsoclonus-myoclonus-ataxia syndrome		OU: involuntary and conjugate horizontal eye movements	IV methylprednisolone 1 g daily, IVIg 0.4 g/kg daily for 5 days, prednisone taper	Completed	Resolution	8 weeks
Alnabulsi 2018¹³⁰	67M	Melanoma	Ipilimumab and nivolumab	Day 10	Myositis	Normal size	OU: ptosis, ophthalmoplegia	IV methylprednisolone up to 1 g daily IVIg 81 mg for 2 doses, IV infliximab 400 mg for 1 dose	Terminated	No improvement, death (cardiac arrest, multi-organ failure)	NR
Bourgeois-Vionnet 2018¹²⁶	79NR	Lung adenocarcinoma	Nivolumab	2 injections: then 1 week	Myositis	Normal size (assumed)	OU: ptosis	IVIg, po corticosteroids 1 mg/kg daily for 6 months	Terminated	Resolution	6
Carrera 2017¹³¹	68M	NSCLC	Tremelimumab and durvalumab	2 doses: then 4 days	Myositis	NR	OU: diplopia, OS: hypertropia, ptosis	60 mg prednisone then taper	Terminated	Resolution (1 month)	6
Diamantopoulos 2017¹²⁹	82M	Melanoma	Pembrolizumab	1 infusion: then 15 days	Myositis	NR	OS: ptosis, miosis, OU: diplopia	Prednisolone 75 mg, IVIg 0.3 g/kg daily, plasmapheresis	Terminated	Improvement, death (respiratory failure)	34 days
Hamada 2018¹²⁸	83M	Lung adenocarcinoma	Pembrolizumab	2 cycles: then 1 week	Myositis	NR	OD: ptosis	Systemic prednisone 40 mg/day	Terminated	Resolution	2
Hellman 2019¹²⁷	83M	Urothelial carcinoma	Pembrolizumab	2 cycles	Myositis	NR	OU: ptosis, ophthalmoplegia	Prednisone 1 mg/kg daily, later IV methylprednisolone	Terminated	Improvement, death (pneumothorax)	33 days
Kang 2018¹³³	75M	HNSCC	Nivolumab	1 infusion: then 3 weeks	Myositis	Normal size (assumed)	OU: ptosis	IV methylprednisolone 80 mg daily for 3 weeks, then prednisone 100 mg daily, plasmapheresis, a trial of pyridostigmine 60 mg	Terminated	No improvement, death (cardiac arrest)	2
Khoo 2019¹³²	80F	Urothelial cancer	Atezolizumab	8 weeks	Myositis	Normal size (assumed)	OU: ptosis	IV methylprednisolone 1 g daily for 3 days, IVIg 2 g/kg total dose, po prednisolone slow taper	Terminated	Improvement with residual ptosis	3
Kao 2017³⁸	Age NR, F	Leiomyosarcoma	Nivolumab	3 cycles	Internuclear ophthalmoplegia		OU: internuclear ophthalmoplegia	Corticosteroid (dose NR) for 1 week	Continued	Improvement	NR
Mancone 2018²⁴	75M	Lung squamous cell carcinoma	Nivolumab	3 cycles	Oculomotor nerve palsy		OU: diplopia, OD: ptosis	Prednisone taper	Terminated	Resolution	NR

Abbreviations: NSCLC, non-squamous cell lung cancer; HNSCC, head and neck squamous cell carcinoma; OU, both eyes; OD, right eye; OS, left eye; IV, intravenous; po, per os; IVIg, intravenous immunoglobulin; NR, not reported; PLEX, plasma exchange; BID, twice daily; TID, three times daily; QID, four times daily; TED, thyroid-like eye disease.