Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 3;13:11265–11275. doi: 10.2147/OTT.S274744

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Pan et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

miR-1297 is downregulated in OS cell lines and closely related to apoptosis and proliferation of the OS cells. (A) The representative expression level of miR-1297 in hFOB1.19 (normal osteoblast cell line) and Saos-2, U-2OS, MNNG-HOS and MG-63 (OS cell lines). **p < 0.01, ***p < 0.001. (B) The overexpression efficacy of miR-1297 in MNNG-HOS and U-2OS (wild OS cells) was verified by qRT-PCR, **p < 0.01. (C and D) Overexpression of miR-1297 inhibited the proliferation of MNNG-HOS and U-2OS cells using the cell counting kit (CCK)-8 assay, Values are means ± SD, **p < 0.01. (E) Upregulated of miR-1297 suppressed the proliferation of MNNG-HOS and U-2OS cells (OS cells lines verified determined by colony formation assay, Values are means ± SD, **p < 0.01). (F and G) Upregulated of miR-1297 signiﬁcantly induces apoptosis of MNNG-HOS and U-2OS (OS cells lines), Values are means ± SD, **p<0.01.