Table 2.
Outcomes in propensity score-weighted patients stratified by trial eligibility
| Variable | No. of events | Person-years | Event rate | No. of events | Person-years | Event rate | Absolute reduction in event rate (95% CI) | Hazard ratio (95% CI) | P |
|---|---|---|---|---|---|---|---|---|---|
| Overall | Drug treated (n = 282,366) | Ablated (n = 7465) | |||||||
| Composite of all-cause mortality and HF hospitalization | 1099 | 88.49 | 12.42 | 927 | 93.24 | 9.94 | −2.48 (−3.18 to −1.79) | 0.81(0.76 to 0.87) | <.001 |
| All-cause mortality | 696 | 95.46 | 7.29 | 495 | 101.18 | 4.89 | −4.33 (−5.16 to −3.51) | 0.67 (0.62 to 0.74) | <.001 |
| HF hospitalization | 576 | 88.49 | 6.50 | 587 | 93.24 | 6.30 | −0.21 (−0.74 to −0.33) | 1.02 (0.94 to 1.10) | .666 |
| Trial eligible | Drug treated (n = 21,824) | Ablated (n = 704) | |||||||
| Composite of all-cause mortality and HF hospitalization | 187 | 7.68 | 24.32 | 155 | 7.90 | 19.64 | −4.68 (−8.19 to −1.17) | 0.82 (0.70 to 0.96) | .014 |
| All-cause mortality | 101 | 9.04 | 11.18 | 76 | 9.13 | 8.32 | −4.60 (−7.75 to −1.44) | 0.75 (0.60 to 0.94) | .011 |
| HF hospitalization | 131 | 7.68 | 17.00 | 112 | 7.90 | 14.22 | −2.79 (−5.70 to 0.13) | 0.87 (0.72 to 1.04) | .127 |
| Failed to meet inclusion | Drug treated (n = 5 216,095) | Ablated (n = 6314) | |||||||
| Composite of all-cause mortality and HF hospitalization | 801 | 75.60 | 10.60 | 661 | 79.90 | 8.27 | −2.33 (−3.01 to −1.65) | 0.79 (0.73 to 0.86) | <.001 |
| All-cause mortality | 520 | 80.65 | 6.45 | 353 | 85.72 | 4.12 | −4.27 (−5.12 to −3.43) | 0.64 (0.58 to 0.71) | <.001 |
| HF hospitalization | 389 | 75.60 | 5.15 | 401 | 79.90 | 5.02 | −0.13 (−0.64 to 0.38) | 1.02 (0.93 to 1.13) | .630 |
| Met exclusion criteria | Drug treated (n = 5 44,447) | Ablated (n = 447) | |||||||
| Composite of all-cause mortality and HF hospitalization | 112 | 5.21 | 21.41 | 111 | 5.44 | 20.40 | −1.02 (−5.20 to 3.17) | 0.97 (0.81 to 1.17) | .746 |
| All-cause mortality | 75 | 5.77 | 13.06 | 65 | 6.33 | 10.33 | −4.48 (−8.78 to −0.19) | 0.80 (0.63 to 1.02) | .072 |
| HF hospitalization | 56 | 5.21 | 10.68 | 74 | 5.44 | 13.53 | 2.85 (−0.42 to 6.13) | 1.35 (1.07 to 1.70) | .012 |
Event rate was calculated as the number of events per 100 person-years. Propensity score weight was applied when calculating number of events, person-years, event rates, absolute reduction, and hazard ratios. CI = confidence interval;HF = heart failure.