Circadian period is shortened and jetlag re-entrainment is accelerated in Tfap2b+/− mice. (A) Daily activity, two-way ANOVA test followed by Sidak’s pairwise comparison, the main effect of genotype: F(1, 480) = 13.12, ***P = 0.0003; the main effect of time, F(47, 480) = 65.66, P < 0.0001. (B) Total activity, P = 0.310, Mann-Whitney test. (C) Activity in light phase, P = 0.558, Mann-Whitney test. (D) Six hours phase advance two-way ANOVA test followed by Sidak’s pairwise comparison, the main effect of genotype, F(1, 160) = 24.82, ****P < 0.0001; the main effect of time, F(15, 160) = 161.1, P < 0.0001; 50% phase shift (PS50): two-tailed unpaired t-test, *P = 0.0273. (E) Phase shift, P = 0.452, Mann-Whitney test. (F) Locomotor activity during light pulse, P = 0.558, Mann-Whitney test. (G) Free-running period during constant darkness, *P = 0.022, Mann-Whitney test. All data are shown as the mean ± SEM n = 6 for Tfap2b+/+, n = 6 for Tfap2b+/−.