Table 2.
LP PC and LP PC: SPM hydrodynamic diameter, polydispersion index (PdI), zeta potential, encapsulation efficiency (EE), and drug recovery (DR) before and after a 2 mA-electric current application (n = 3).
| Formulations | Time (min) | Hydrodynamic diameter (nm) | PdI | Zeta potential (mV) | EE (%) | DR (%) |
|---|---|---|---|---|---|---|
| Besifloxacin solution | 0 | – | – | – | – | 100.0 |
| 30 | – | – | – | – | 95.3 ± 0.6 | |
| LP PC | 0 | 177.2 ± 2.6 | 0.019 ± 0.011 | − 5.7 ± 0.3** | 51.8 ± 1.9* | 100.0 |
| 30 | 178.6 ± 8.9 | 0.034 ± 0.020 | − 1.4 ± 0.1** | 42.2 ± 2.0* | 105.6 ± 2.3 | |
| LP PC:SPM | 0 | 175.4 ± 1.9 | 0.071 ± 0.032 | 19.5 ± 1.0** | 63.3 ± 1.8 | 100.0 |
| 30 | 174.1 ± 2.2 | 0.075 ± 0.021 | 24.3 ± 2.5** | 60.8 ± 6.4 | 99.9 ± 1.3 |
*(p ≤ 0.05, ANOVA),**(p ≤ 0.01, ANOVA).