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. 2020 Nov 6;11(11):955. doi: 10.1038/s41419-020-03140-2

Fig. 2. The pathways of PD-L1 autophagic degradation.

Fig. 2

HIP1R, PKCα/GSK3β/MITF, ADAM10/17, and endosomal sorting-signal induce PD-L1 protein degradation by autophagy, which is inhibited by CMTM6, DHHC3, and Sigma I. In response to extracellular stimuli or specific anti-PD-L1 antibody such as HA or STM108, PD-L1 protein is degraded via autophagy.