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. 2020 Nov 6;11:5652. doi: 10.1038/s41467-020-19415-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Genome organization of the Klebsiella pneumoniae ABFQB plasmid unitig_1 (CP036439.1), highlighting the anti-defense cluster region. Genes are colored according to their predicted functions as shown in the key. Coding regions encoded on the plus and minus strands are shown on the outer and inner lanes of the gene map, respectively. b Examples of genomic regions within diverse MGEs where acrs were found in the vicinity of known anti-RM genes and other putative anti-defense determinants. Genes are colored according to the gene key in (a).