Table 7.
Effect of Independent Process Variables on Dependent Variable by Box-Behnken Design (C-SD)
| Preparation Code | Real Value (Coded Level) | Solaq (mg/mL) | Rel5min (%) | ||||
|---|---|---|---|---|---|---|---|
| Actual | Predicted | Actual | Predicted | ||||
| X1 | X2 | X3 | Y1 | Y1 | Y2 | Y2 | |
| P1 | 300 (−1.00) | 600 (−1.00) | 80 (0.00) | 0.98 | 0.98 | 73.82 | 73.92 |
| P2 | 700 (1.00) | 600 (−1.00) | 80 (0.00) | 1.26 | 1.27 | 75.43 | 75.69 |
| P3 | 300 (−1.00) | 800 (1.00) | 80 (0.00) | 1.03 | 1.03 | 72.85 | 72.59 |
| P4 | 700 (1.00) | 800 (1.00) | 80 (0.00) | 1.27 | 1.27 | 75.24 | 75.14 |
| P5 | 300 (−1.00) | 700 (0.00) | 70 (−1.00) | 1.09 | 1.09 | 78.25 | 78.27 |
| P6 | 700 (1.00) | 700 (0.00) | 70 (−1.00) | 1.35 | 1.36 | 78.67 | 78.53 |
| P7 | 300 (−1.00) | 700 (0.00) | 90 (1.00) | 1.06 | 1.06 | 75.81 | 75.95 |
| P8 | 700 (1.00) | 700 (0.00) | 90 (1.00) | 1.30 | 1.31 | 80.03 | 80.01 |
| P9 | 500 (0.00) | 600 (−1.00) | 70 (−1.00) | 1.21 | 1.21 | 80.25 | 80.14 |
| P10 | 500 (0.00) | 800 (1.00) | 70 (−1.00) | 1.25 | 1.25 | 78.71 | 78.95 |
| P11 | 500 (0.00) | 600 (−1.00) | 90 (1.00) | 1.19 | 1.19 | 79.71 | 79.47 |
| P12 | 500 (0.00) | 800 (1.00) | 90 (1.00) | 1.19 | 1.20 | 78.68 | 78.79 |
| P13 | 500 (0.00) | 700 (0.00) | 80 (0.00) | 1.23 | 1.23 | 81.52 | 81.42 |
| P14 | 500 (0.00) | 700 (0.00) | 80 (0.00) | 1.22 | 1.23 | 81.04 | 81.42 |
| P15 | 500 (0.00) | 700 (0.00) | 80 (0.00) | 1.23 | 1.23 | 81.02 | 81.42 |
| P16 | 500 (0.00) | 700 (0.00) | 80 (0.00) | 1.23 | 1.23 | 81.50 | 81.42 |
| P17 | 500 (0.00) | 700 (0.00) | 80 (0.00) | 1.22 | 1.23 | 82.00 | 81.42 |
Notes: X1 – carrier concentration (mg); X2– stirring speed (rpm); and X3– temperature (°C) and Y1– aqueous solubility (mg/mL); and Y2– release at 5 minutes (%).