Table 3.
Rates of cervical intraepithelial neoplasia (CIN) diagnoses according to the interaction between HPV type 16 and HPV33, 51, 52, and 66.
| CIN 1 | CIN 2 | CIN 3 | Invasive cancer | |
|---|---|---|---|---|
| (n) 1811 (%) | (n) 405 (%) | (n) 678 (%) | (n) 91 (%) | |
| Single HPV 16 (n = 491) | 246 (13.6)# | 75 (18.5) | 140 (20.6)∗ | 30 (33)∗ |
| HPV16 and HPV18 negative (n = 1972) | 1296 (71.6)∗ | 256 (63.2)# | 377 (55.6)# | 43 (47.2)# |
| HPV16 and HPV18 positive (n = 99) | 36 (2)# | 13 (3.2) | 45 (6.6)∗ | 5 (5.5) |
| Single HPV 18 (n = 65) | 42 (2.3) | 9 (2.2) | 11 (1.6) | 3 (3.3) |
| Multiple HPV 16 (no HPV 18) n = 298 | 156 (8.6)# | 41 (10.1) | 93 (13.7)∗ | 8 (8.9) |
| Multiple HPV 18 (no HPV 16) n = 60 | 35 (1.9) | 11 (2.7) | 12 (1.8) | 2 (2.2) |
| HPV16 and HPV33 negative (n = 1991) | 1325 (73.2) | 253 (62.5) | 368 (54.3) | 45 (49.4) |
| HPV 16 and HPV 33 positive (n = 25) | 14 (0.8) | 3 (0.7) | 8 (1.3) | 0 (−) |
| Single HPV 33 (n = 57) | 23 (1.3) | 16 (3.95) | 16 (2.4) | 2 (2.2) |
| Multiple HPV 16 (no HPV 33) (n = 375) | 178 (9.8)# | 51 (12.6) | 130 (19.2) | 16 (17.6) |
| Multiple HPV 33 (no HPV 16) (n = 49) | 25 (1.4) | 7 (1.7) | 16 (2.4) | 1 (1.1) |
| HPV16 and HPV51 negative (n = 1565) | 1190 (65.7)# | 236 (58.3) | 335 (49.4)# | 40 (44)# |
| HPV16 and HPV51 positive (n = 85) | 52 (2.9) | 11 (2.7) | 20 (2.9) | 2 (2.2) |
| Single HPV 51 (n = 156) | 97 (5.4) | 23 (5.7) | 32 (4.7) | 4 (4.4) |
| Multiple HPV 16 (no HPV 51) (n = 312) | 140 (7.7)# | 43 (10.6) | 118 (17.4)∗ | 11 (12.1) |
| Multiple HPV 51 (no HPV 16) (n = 131) | 77 (4.2) | 17 (4.2) | 33 (4.9) | 4 (4.4) |
| HPV16 and HPV52 negative (n = 1598) | 1080 (59.6)# | 209 (51.6) | 278 (41)∗ | 31 (34.1)∗ |
| HPV16 and HPV52 positive (n = 157) | 64 (3.5)# | 20 (5) | 65 (9.6)∗ | 8 (8.8) |
| Single HPV 52 (n = 219) | 141 (7.8) | 31 (7.6) | 42 (6.2) | 5 (5.5) |
| Multiple HPV 16 (no HPV 52) (n = 240) | 128 (7.1)# | 34 (8.4) | 73 (10.8)∗ | 5 (5.5) |
| Multiple HPV 52 (no HPV 16) (n = 280) | 152 (8.4) | 36 (8.9) | 80 (11.8) | 12 (13.2) |
| HPV16 and HPV66 negative (n = 1836) | 1273 (70.3)# | 252 (62.2) | 373 (55)# | 38 (41.8)# |
| HPV16 and HPV66 positive (n = 33) | 23 (1.3) | 4 (1) | 5 (0.8) | 1 (1.1) |
| Single HPV66 (n = 88) | 56 (3.1) | 10 (2.5) | 18 (2.6) | 4 (4.4) |
| Multiple HPV 16 (no HPV 66) (n = 364) | 169 (9.3)# | 50 (12.3) | 133 (19.6)∗ | 12 (13.2)∗ |
| Multiple HPV 66 (n = 73) | 44 (2.4) | 14 (3.5) | 9 (1.3) | 6 (6.6) |
CIN: cervical intraepithelial neoplasia. HPV: human papilloma virus. ∗p < .05 higher than expected rate by the chi-squared test and post-hoc analysis with Bonferroni correction #p < .05 lower than expected rate by the chi-squared test and post-hoc analysis with Bonferroni correction.