Table 4.
Comparison of diagnostic value among COMPASS 31 score and HRV indices.
| Variables | Cutoff | Sensitivity (%) |
Specificity (%) |
PPV (%) |
NPV (%) |
AUC | Youden's index | Kappa value |
|---|---|---|---|---|---|---|---|---|
| COMPASS 31 score | >19.5 | 67.4 | 83.3 | 74.4 | 78.1 | 0.816 | 0.51 | 0.52 |
| HRV indices | ||||||||
| SDNN (ms) | ≤95 | 79.1 | 91.7 | 87.2 | 85.9 | 0.919 | 0.71 | 0.72 |
| PNN50 (%) | ≤1.4 | 58.1 | 86.7 | 75.8 | 74.3 | 0.746 | 0.45 | 0.46 |
| RMSSD (ms) | ≤16 | 44.2 | 88.3 | 73.1 | 68.8 | 0.648 | 0.33 | 0.34 |
| LF (ms2) | ≤131.4 | 65.1 | 96.7 | 93.3 | 79.5 | 0.865 | 0.62 | 0.65 |
| HF (ms2) | ≤183.5 | 83.7 | 61.7 | 61.0 | 84.1 | 0.747 | 0.45 | 0.43 |
| LF/HF ratio | ≤0.86 | 48.8 | 88.3 | 75.0 | 70.7 | 0.699 | 0.37 | 0.39 |
| Combined model | / | 90.7 | 86.7 | 83.0 | 92.9 | 0.958 | 0.77 | 0.75 |
Combined model: the combination of COMPASS 31 score, SDNN, and LF. COMPASS 31: Composite Autonomic Symptom Score 31; HRV: heart rate variability; SDNN: the standard deviation of the NN intervals; PNN50: the percentage of adjacent NN intervals with a difference greater than 50 ms; RMSSD: the root mean square differences of successive NN intervals; LF: low-frequency power; HF: high-frequency power.