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. 2020 Oct 31;2020:5454210. doi: 10.1155/2020/5454210

Figure 1.

Figure 1

DEX improves survival rate and attenuates kidney damage induced by LPS. (a) Survival rates of septic mice, 10, 30, and 50 μg/kg DEX pretreatment groups (∗∗p < 0.01, versus control; #p < 0.05 versus LPS, n = 10 per group; log-rank (Mantel-Cox) test). (b, c) Cr and BUN levels in serum. (d) Histopathological changes in kidney tissues (scale bar = 50 μm); yellow arrow indicates tubular necrosis and vacuolar degeneration. (e) Tubular injury score (∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.0001 versus control; ##p < 0.01 versus LPS. Data were presented as mean ± SEM, n = 6). H&E: hematoxylin and eosin; PAS: Periodic Acid-Schiff stain.