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. 2020 Oct 31;2020:5454210. doi: 10.1155/2020/5454210

Figure 3.

Figure 3

Dexmedetomidine suppressed apoptosis in AKI induced by LPS. (a, b) TUNEL staining in kidney sections of mice (scale bar = 50 μm), white arrows to show TUNEL-positive nuclei and quantitation of TUNEL-positive cells. (c, d) Cleaved caspase-3 staining in kidney sections of mice (scale bar = 50 μm), and quantitation of Cleaved caspase-3-positive cells. (e, f) Western blot analysis and quantitative data for Cleaved caspase-3, p75NTR, proNGF, and NGF in kidney tissues of mice; GAPDH was used as a loading control. (g) p75NTR, NGF, TrkA, and Sortilin gene expression in the kidney tissues of mice (∗p < 0.05 and ∗∗p < 0.01 versus control; #p < 0.05 and ##p < 0.01 versus LPS. Data were presented as mean ± SEM, n = 6).