Table 1.

Genetic Syndromes of Diabetes.

Gene	Protein	Syndrome	Inheritance
INS	Insulin	Permanent Neonatal Diabetes Mellitus	Autosomal domiant
EIF2AK3	PERK	Walcott-Rallison Syndrome	Autosomal recessive
EIF2S	eIF2γ	MEHMO Syndrome	X-linked recessive
PPP1R15B	CReP	MSSGM2	Autosomal recessive
DNAJC3	p58IPK	ACPHD	Autosomal recessive
IER3IP1	IER3IP1	MEDS	Autosomal recessive
WFS1	Wolframin	Wolfram Syndrome 1	Autosomal recessive*
CISD2	CISD2	Wolfram Syndrome 2	Autosomal recessive

MEHMO = Mental Retardation, Epileptic Seizures, Hypogonadism, and Hypogenitalism, Microcephaly, and Obesity; MSSGM2 = Microcephaly, short stature, and impaired glucose metabolism-2; ACPHD = Ataxia, Combined Cerebellar and Peripheral, with Hearing Loss, and Diabetes Mellitus; MEDS = Microcephaly, Epilepsy, and Diabetes Syndrome.

^*The majority of Wolfram syndrome 1 cases are autosomal recessive, however a small subset of patients carry only one mutant WFS1 allele.