Table 2.

Univariable and multivariable analysis on the occurrence of serious infections in older anti-TNF users and older non-users, using follow-up time from date of diagnosis until 3 months after last administration of anti-TNF therapy or end of follow-up

	Univariable analysis			Multivariable analysis
	HR	95% CI	P	HR	95% CI	P
Anti-TNF therapy	5.131	1.679–15.684	0.004	3.920	1.185–12.973	0.025
Age at diagnosis	1.026	0.997–1.057	0.078	1.018	0.987–1.049	0.264
Comorbiditya
1	1.308	0.550–3.112	0.544	1.164	0.487–2.785	0.733
2 or more	1.202	0.445–3.247	0.717	0.999	0.363–2.751	0.998

HR hazard ratio, CI confidence interval, TNF tumor necrosis factor

^aReference is zero comorbidities