Table 1.
Tissue wise enriched KEGG pathways and associated genes.
| Tissue | KEGG pathway | Count | Fold enrichment | − log10 (p-value) | Genes |
|---|---|---|---|---|---|
| Liver | Cell cycle | 16 | 4.728913 | 6.076795 | CDK1, CDC20, MCM2, PTTG1, MCM3, CDK2, MCM5, WEE1, MCM6, CCNB3, MAD2L1, CCNB2, PLK1, BUB1B, CCNA2, ORC1 |
| Pyruvate metabolism | 8 | 7.649713 | 4.244594 | LDHB, LDHA, ACACA, PDHA1, PCK2, PDHB, PCK1, PC | |
| DNA replication | 7 | 7.585965 | 3.629713 | DNA2, RFC3, RFC2, MCM2, MCM3, MCM5, MCM6 | |
| PPAR signaling pathway | 9 | 4.959348 | 3.438575 | LPL, PLIN1, APOC3, PPARG, FABP1, PCK2, CPT1A, PCK1, ACAA1 | |
| Glycolysis/gluconeogenesis | 8 | 5.099808 | 3.099527 | LDHB, LDHA, ALDOC, PGM1, PDHA1, PCK2, PDHB, PCK1 | |
| Biosynthesis of antibiotics | 15 | 2.679501 | 2.937769 | LDHB, LDHA, ASL2, ALDOC, HMGCS1, PCK2, HADHA, PDHB, PCK1, PYCR2, PGM1, PDHA1, CAT, UGP2, ACAA1 | |
| Citrate cycle (TCA cycle) | 5 | 5.805585 | 2.016859 | PDHA1, PCK2, PDHB, PCK1, PC | |
| Breast | Biosynthesis of antibiotics | 20 | 5.001735 | 8.187750758 | LDHA, PFKL, PGAM1, IDH3B, LSS, PFKM, FDFT1, GART, PKM, GOT2, GPI, NME5, TPI1, PGP, SQLE, PGM1, ENO3, SUCLA2, PGK1, GAPDH |
| Glycolysis/gluconeogenesis | 11 | 9.817131 | 7.050261023 | PKM, GPI, LDHA, TPI1, PFKL, PGM1, PGAM1, ENO3, PFKM, PGK1, GAPDH | |
| Carbon metabolism | 14 | 6.637719 | 7.017104542 | PKM, GOT2, GPI, PGP, TPI1, PFKL, MCEE, PGAM1, ENO3, IDH3B, PFKM, PGK1, SUCLA2, GAPDH | |
| Biosynthesis of amino acids | 11 | 8.783749 | 6.56804503 | PKM, GOT2, GLUL, TPI1, PFKL, PGAM1, ENO3, IDH3B, PFKM, PGK1, GAPDH | |
| Metabolic pathways | 37 | 1.590259 | 2.732261046 | LDHA, ATP5B, PGAM1, LSS, HIBADH, FDFT1, GOT2, PKM, MTHFD2, PGP, TPI1, CRYL1, ST6GALNAC4, MCEE, CKMT2, ENO3, SUCLA2, BDH1, GAPDH, DHCR24, PDXK, GATM, PFKL, AMACR, EPHX2, IDH3B, PFKM, GART, GPI, NME5, GLUL, SQLE, GLS, PGM1, PGK1, AMY1A, MPST | |
| Steroid biosynthesis | 4 | 10.7096 | 2.265676219 | SQLE, LSS, FDFT1, DHCR24 | |
| PPAR signaling pathway | 6 | 4.628724 | 2.062731216 | SLC27A1, LPL, CPT2, APOC3, ADIPOQ, FABP5 | |
| Caecum | Cell cycle | 12 | 6.206699 | 5.660312 | CDK1, CCNB3, CCNB2, MAD2L1, PLK1, BUB1, BUB1B, CDC20, MCM2, PTTG1, CCNA2, CDK2 |
| Oocyte meiosis | 9 | 5.7534 | 3.891816 | CDK1, CCNB2, MAD2L1, PLK1, SGOL1, BUB1, CDC20, PTTG1, CDK2 | |
| Progesterone-mediated oocyte maturation | 8 | 6.068772 | 3.560625 | CDK1, CCNB3, CCNB2, MAD2L1, PLK1, BUB1, CCNA2, CDK2 | |
| p53 signaling pathway | 6 | 5.596204 | 2.416468 | CDK1, CCNB3, CCNB2, CYCS, CDK2, GTSE1 | |
| Glutathione metabolism | 4 | 5.98892 | 1.562493 | GPX2, GSTA3, RRM1, GSTO1 | |
| Pyrimidine metabolism | 5 | 3.307834 | 1.214186 | DCTD, RRM1, DGUOK, UCK2, TK1 | |
| Gizzard | Cell adhesion molecules (CAMs) | 10 | 4.779485 | 3.730487 | PTPRC, CD86, CD80, DMA, CLDN10, ITGB2, CDH2, SDC4, YF5, DMB2 |
| Phagosome | 10 | 4.270196 | 3.360878 | TUBB, MBL, TFRC, C3, DMA, ITGB2, TLR4, CTSS, YF5, DMB2 | |
| MAPK signaling pathway | 10 | 2.469023 | 1.757301 | BDNF, RAC2, MAP2K3, NTRK2, FGF13, GADD45B, FGF1, GADD45A, MYC, CACNA1B | |
| Toll-like receptor signaling pathway | 6 | 3.766004 | 1.701982 | CTSK, CD86, CD80, MAP2K3, TLR4, TLR7 | |
| Intestinal immune network for IgA production | 4 | 6.722114 | 1.695366 | CD86, CD80, DMA, DMB2 | |
| Cytokine-cytokine receptor interaction | 7 | 2.497772 | 1.241337 | CCR5, CCR8L, CCR2, LOC418666, IL2RG, XCR1, PRL | |
| Calcium signaling pathway | 7 | 2.26506 | 1.07805 | CCKAR, SLC8A1, ATP2A3, ERBB2, BDKRB2, CAMK2A, CACNA1B | |
| Biosynthesis of amino acids | 4 | 3.655887 | 1.032526 | GLUL, MAT1A, ALDOB, PAH |