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. 2020 Nov 6;11(11):953. doi: 10.1038/s41419-020-03160-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a miR-185-5p has a predicted binding site in p66Shc from humans and mice. b Liver miR-185-5p expression, n = 6. c Hepatocytes miR-185-5p expression, n = 6. ^*p < 0.05, ^**p < 0.01 vs. the control group. d, e AML12 cells were transfected with agomir-NC or miR-185-5p agomir. d miR-185-5p expression, n = 6. e p66Shc protein, n = 3. ^**p < 0.01 vs. the ago-NC group. f, g AML12 cells were transfected with antagomir-NC or miR-185-5p antagomir. f miR-185-5p expression, n = 6. g p66Shc protein, n = 3. ^**p < 0.01 vs. the ant-NC group. h AML12 cells were transfected with wild-type or mutant SHC1-3′-UTR luciferase constructs and with agomir-NC or miR-185-5p agomir. Luciferase activity was detected 48 h after transfection. ^**p < 0.01 vs. the ago-NC group.