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. 2020 Nov 6;11(11):953. doi: 10.1038/s41419-020-03160-y

Fig. 7. circ-CBFB functions in APAP-induced hepatocyte injury by targeting miR-185-5p.

Fig. 7

AML12 cells were transfected with si-control or si-CBFB and ant-NC or miR-185-5p antagomir and then exposed to APAP. a circ-CBFB expression, n = 6. b, c p66Shc, OMA1, S-OPA1, MFN2, DRP1, and p-DRP1 proteins, n = 3. d Mitochondrial fragmentation was determined via representative fluorescence images of TOM20-stained cells. Scale bar, 12.5 μm. e, f p66Shc, OMA1, S-OPA1, MFN2, DRP1, and p-DRP1 proteins, n = 3. g Mitochondrial fragmentation was determined via representative fluorescence images of TOM20-stained cells. Scale bar, 12.5 μm. **p < 0.01 vs. the si-control group; ##p < 0.01 vs. the APAP group; &&p < 0.01 vs. the si-CBFB group.