Fig. 1. Global patterns of alternative splicing patterns in the Pten^m3m4 mouse brain.

a Schematic pipeline for analysis of alternative splicing patterns from RNA-sequencing data using rMATS (N = 3 for each genotype at each time point). b Summary of inclusion and exclusion events for MUT vs. WT comparison by event type for P14 and P40 time points. c, d ΔΨ distributions by event type for MUT vs. WT comparison for both P14 and P40 time points (*p < 0.05). SE exon skipping, RI retained intron, A3SS alternative 3′ splice site; A5SS alternative 5′ splice site.