| Why carry out this study? |
| Tension-type headache (TTH) is the most prevalent primary headache. |
| The treatment of chronic TTH is complex and very often associated with significant tolerability issues. |
| The aim of this surveillance program was to evaluate the efficacy of melatonin in patients with TTH and disruption of circadian rhythms in real-world practice. |
| What was learned from the study? |
| Sixty-one patients with chronic TTH were treated with melatonin 3 mg before bedtime for 30 days with a follow-up of another 30 days. |
| A significant decrease in headache frequency and an improvement in multiple secondary endpoints were observed across the treatment and follow-up phases. |
| Melatonin is a useful treatment for patients with chronic TTH and sleep disorders. |
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