Gabapentinoids are an important tool in the pain physician’s multimodal armamentarium for the management of many types of pain processes.

Individuals with central sensitization and pain associated with slow-wave sleep deficits and potentially persons with addictions pain syndromes may benefit the most.

The gabapentinoids appear to possess no addictive potential themselves, based on laboratory and clinical data.

Gabapeninoids may be abused by persons with opioid use disorders, and cautious risk stratification must take place.