Fig. 1. Anatomical separability of the clusters.

a Structure coefficients. The highlighted regions indicate the importance of each region for multi-class anatomical classification. The positive values are associated with an increased cortical thickness (yellow) and the negative values are in association with the reduced cortical thickness (blue), relative to the other classes. For the purposes of illustration, the structure coefficients were thresholded at P<0.001 however this should not be a formal statistical test since these were estimated under cross-validation⁶⁸. b The average deviations from normative CT across clusters. Respectively, blue and yellow vertices indicate reduced and increased CT relative to the reference cohort. Maps were rescaled for visualization such that the maximum in each image was = 1.