Table 1.

Anti-diabetic properties of Swertia chirayita

Therapeutic properties evaluated	Part of plant used	Solvent used for extraction	Test organism or model	Outcomes	References
Hypoglycemic and hypolipidemic properties	Whole plant	Directly dried and grinded material was used	Diabetes patients	Glucose level, triglycerides level, cholesterol level and level of LDL cholesterol decreased 14.5%, 10.5%, 8.6%, 14.4% respectively	[74]
Anti-hyperglycemic properties	Root extract	Ethanol	Swiss albino Wister rats	Decreases glucose, insulin levels and also improves lipid levels almost similar to the result of standard drug	[75]
Anti-hyperglycemic Properties	Stem-bark	Ethanol and water	nSTZ-T2DM rats	Substantial reduction in fasting glucose, cholesterol, triglycerides level and improvement in hepatic glycogen content	[76]
Antidiabetic Properties	Fresh tender leaves	Distilled water	Streptozotocin induced diabetic albino rats	Blood glucose levels in diabetic rats were reduced from 250.62 ± 2.35 mg/dl to 86.5 ± 2.85 mg/dl on 21st day	[77]
Hypoglycemic effect	Whole plant	Percolation with 95% ethanol and further concentrated with n-hexane	Tolbutamide pre-treated albino rat	Reduction of 40% blood sugar level	[61]
Lowering blood sugar	Whole plant	Hexane fraction	CF rats	Glucose consumption and glycogen development by muscle was improved and Blood glucose level was lowered by stimulating insulin release	[78]
Anti-diabetic properties	Different part of the plant like root, shoot and leaf	Crude aqueous and 12% ethanol	–	Existence of phytochemicals like mangiferin, swertiamarin, and amarogentin and their derivatives with anti-hyperglycemia potential was proved in crude plant extracts	[63]
Antidiabetic properties	Whole plant	Methanol	–	Analytical assays validated the presence of swertiamarin, mangiferin, amaroswerin, sweroside and amarogentin in plant extract	[79]