Table 1.
Demographic characteristics, medical history and laboratory results of the two whole cohort of COVID-19 patients enrolled in the study, and of the subcohorts of patients with and without VTE at the time of hospital admission
| All patients (n = 259) |
VTE (n = 25) |
Non-VTE (n = 234) |
p value | |
|---|---|---|---|---|
| Median age, years (range) | 70 (25–97) | 62 (44–84) | 70 (25–97) | 0.005 |
| Sex | ||||
| Female | 66 (25–94) | 63 (44–84) | 69 (25–94) | 0.006 |
| n. (%) | (32) | (24) | (32) | |
| Male | 74 (27–97) | 62 (51–79) | 79 (27–97) | 0.002 |
| n. (%) | (68) | (76) | (68) | |
| Padua score | ||||
| > 4 | 226 | 25 | 202 | 0.4 |
| n. (%) | (87) | (100) | (86) | |
| ≤ 4 | 45 | 0 | 45 | < 0.0001 |
| n. (%) | (13) | (0) | (14) | |
| Ventilation | ||||
| Non-invasive ventilation | 205 | 16 | 189 | 0.2 |
| n. (%) | (79) | (64) | (81) | |
| Invasive mechanical ventilation | 54 | 9 | 45 | 0.29 |
| n. (%) | (21) | (36) | (19) | |
| Anticoagulant prophylactic therapy | ||||
| Enoxaparin | 206 | 14 | 192 | 0.07 |
| n. (%) | (79) | (56) | (82) | |
| Fondaparinux | 3 | 2 | 1 | 0.06 |
| n. (%) | (1) | (8) | (4) | |
| Calcic heparin | 30 | 7 | 23 | 0.03 |
| n. (%) | (12) | (28) | (10) | |
| Department | ||||
| Subintensive/intermediate care | 205 | 16 | 189 | 0.07 |
| n. (%) | (79) | (64) | (81) | |
| Intensive care unit | 54 | 9 | 45 | 0.04 |
| n. (%) | (21) | (36) | (19) | |
| Laboratory parameters | ||||
| Haemoglobin (g/dl), median (range) | 12.5 (6.8–17.7) | 13.4 (8.9–15.5) | 12.4 (17.7–6.8) | 0.08 |
| Leukocytes (n/µl), median (range) | 7.1 (0.2–91.3) | 9.2 (3.1–17.7) | 6.7 (0.2–91.3) | 0.2 |
| Lymphocytes (n/µl), median (range) | 0.7 (0.02–86.2) | 0.7 (0.2–4.9) | 0.7 (0.1–86.2) | 0.39 |
| NLR, median (range) | 8.2 (0.1–390.5) | 13.7 (2.3–25.1) | 8.2 (0.1–390.5) | 0.5 |
| Platelets (× 103/µl), median (range) | 193 (12–768) | 184 (80–598) | 197 (12–768) | 0.7 |
| LDH (mU/ml), median (range) | 369 (142–4641) | 590 (184–4641) | 369 (142–2578) | 0.04 |
| C-reactive protein (mg/dl), median (range) | 12.3 (0.2–47.4) | 22 (3.5–47.4) | 12.2 (0.2–42.5) | 0.05 |
| Procalcitonine (ng/ml), median (range) | 0.3 (0–206) | 0.4 (0–56.4) | 0.3 (0–206) | 0.9 |
| d-Dimer (µg/l), median (range) | 5181 (555–35,000) | 15,350 (3824–35,000) | 3229 (555–35,000) | 0.09 |
| Interleukin-6 (mg/dl), median (range) | 114.9 (5.7–386.4) | 163.5 (24.2–386.4) | 66.2 (5.7–215.3) | 0.04 |
Statistically significant p-values are indicated in bold
LDH lactate dehydrogenase, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, VTE venous thromboembolism